Stefan Taubert, PhD
Our lab is interested in the regulation of metabolism and of stress responses. In particular, we study how transcriptional regulators adapt genome transcription in response to nutritional cues and various types of stress and the consequences of this for health and aging. These metabolic and stress response pathways are of great biomedical relevance. For example, transcriptional activation of stress response programs helps cancers to grow in hostile microenvironments featuring oxidative stress, starvation, and hypoxia; vice versa, these pathways represent promising pharmacological targets to attack the cancer. To delineate genes and pathways that regulate stress and metabolism, we use the nematode Caenorhabditis elegans, the mouse, and cancer cell lines as genetically tractable models.
Email: taubert@cmmt.ubc.ca