Parkinson’s disease is a common neurodegenerative disorder with increasing worldwide prevalence. Although a number of genes and environmental factors influencing Parkinson’s disease susceptibility have been identified, the mechanisms underpinning their joint contributions to disease pathogenesis are not fully understood. Research in the Kobor lab is investigating the role of DNA methylation, an epigenetic mark which is sensitive to genetics and environment, in Parkinson’s disease.
Members involved: Dr. Michael Kobor, Samantha Schaffner
Recent Publications:
- Alpha-synuclein overexpression induces epigenomic dysregulation of glutamate signaling and locomotor pathways
- DNA methylation as a mediator of genetic and environmental influences on Parkinson’s disease susceptibility: Impacts of alpha-Synuclein, physical activity, and pesticide exposure on the epigenome