Reduced quality and quantity of sleep, which can occur in individuals with obstructive sleep apnea and insomnia, may cause premature aging. This is believed to occur through inflammatory and oxidative stress pathways. By analyzing a large cohort of patients from the sleep clinic, the Ayas and Kobor Labs are investigating whether the severity of obstructive sleep apnea and/or insomnia are associated with accelerated aging based on circulating epigenetic markers.
Members involved: Dr. Najib Ayas and Dr. Michael Kobor